Research Use Only. Semaglutide is sold as a chemical reagent for in-vitro laboratory research. It is not a drug, supplement, or compounded preparation, and it is not for human or veterinary use. Wholesale Peptide Supply is not a pharmacy or compounding facility under 503A or 503B.
Wholesale Semaglutide — Bulk Research Supply
Buy Semaglutide wholesale and in bulk from a US-based research peptide supplier. Every lot is sourced in the USA and third-party third-party tested via HPLC/MS. Bulk Semaglutide is quoted by dose and volume across 100–1,000 vials, mix-and-match across the catalog.
Semaglutide is a synthetic peptide analog that functions as a long-acting pathway agonist, structurally modified for extended half-life and improved target binding affinity. It is studied in preclinical and laboratory models for its ability to activate target pathways and modulate downstream molecular signaling associated with endocrine regulation.
Wholesale Catalog
Available Doses
Published per-vial wholesale pricing for Semaglutide. Sold in boxes of 10 vials with a 100-vial order minimum you can mix and match across compounds; volume pricing applies at 1,000+ vials. Contact us for larger or custom-volume quotes — typically answered within 10 minutes during business hours.
Semaglutide 5mg
CAS 910463-68-2 · GLP-1 & Metabolic
$15/vial · under 1,000 vials · $10/vial · 1,000+
Sold in boxes of 10 vials · 100-vial order minimum (mix & match) · 1,000+ unlocks the lower price
Semaglutide 10mg
CAS 910463-68-2 · GLP-1 & Metabolic
$21/vial · under 1,000 vials · $14/vial · 1,000+
Sold in boxes of 10 vials · 100-vial order minimum (mix & match) · 1,000+ unlocks the lower price
Semaglutide 20mg
CAS 910463-68-2 · GLP-1 & Metabolic
$30/vial · under 1,000 vials · $22/vial · 1,000+
Sold in boxes of 10 vials · 100-vial order minimum (mix & match) · 1,000+ unlocks the lower price
Overview
Semaglutide is a synthetic peptide analog that functions as a long-acting pathway agonist, structurally modified for extended half-life and improved target binding affinity. It is studied in preclinical and laboratory models for its ability to activate target pathways and modulate downstream molecular signaling associated with endocrine regulation.
History
Research into endocrine peptide biology began in the 1980s with the identification of key peptide roles in signaling pathways. Semaglutide was developed with structural modifications — a C18 fatty diacid chain attached via a linker to lysine at position 26 and substitutions at positions 8 and 34 — to improve albumin binding and extend duration of action.
Structure and mechanism
Semaglutide is a 31-amino-acid peptide analog derived from the native GLP-1 backbone. Two substitutions — Aib at position 8 (which resists enzymatic cleavage) and Arg at position 34 — are paired with a C18 fatty diacid chain attached through a γGlu-2xOEG linker to lysine at position 26. That acylation drives reversible albumin binding, which is the structural basis for the compound's extended half-life relative to native GLP-1.
In laboratory models, semaglutide is studied as a long-acting, single-pathway receptor agonist. Research interest centers on receptor binding kinetics, downstream cAMP/PKA signaling, and the comparative behavior of single-pathway agonists against the dual- and triple-pathway compounds (tirzepatide, retatrutide) increasingly used as reference points.
Reconstitution and handling (research use)
Wholesale semaglutide ships as a lyophilized powder. For in-vitro laboratory work it is typically reconstituted with bacteriostatic or sterile water, with the diluent volume chosen to hit the concentration a given assay calls for. Lyophilized material is generally stored at -20°C and protected from light; reconstituted solution is kept refrigerated at 2–8°C and used within the working window appropriate to the study.
These notes describe general laboratory handling of a chemical reagent only. They are not directions for human or veterinary use.
Wholesale sourcing notes
Semaglutide is the highest-demand compound in the current wholesale market, stocked here in 5 mg, 10 mg, and 20 mg presentations. Every lot moves through a controlled US-based supply chain and is verified by an independent third-party lab via HPLC/MS for identity, purity, and quantitation, with a per-lot Certificate of Analysis available as an add-on.
Wholesale pricing is quoted by volume across 100, 250, 500, and 1,000-vial bands under a 100-vial mix-and-match minimum, with a lower price band unlocking at 1,000 vials across the whole order.
Key Areas of Research
- Signaling: pathway dynamics, downstream cascades
- Endocrine: target pathway modulation
- Systemic: lipid pathways, signaling markers
- Receptor binding: albumin-mediated half-life extension
- Comparative studies: single- vs. dual-pathway agonists
References
- Marso S.P. et al. (2016). Semaglutide and cardiovascular outcomes in patients with type 2 diabetes. NEJM, 375:1834–1844.
- Knudsen L.B. et al. (2000). Glucagon-like peptide receptor agonists. Diabetes, 49(12):1978–1984.
- Lau J. et al. (2015). Discovery of the once-weekly GLP-1 analog semaglutide. J Med Chem, 58(18):7370–7380.
- Nauck M.A. & Meier J.J. (2018). Incretin hormones: their role in health and disease. Diabetes Obes Metab, 20(Suppl 1):5–21.
Semaglutide — Frequently Asked Questions
- What is Semaglutide?
- Semaglutide is a synthetic peptide analog that functions as a long-acting pathway agonist, structurally modified for extended half-life and improved target binding affinity. It is studied in preclinical and laboratory models for its ability to activate target pathways and modulate downstream molecular signaling associated with endocrine regulation.
- What is the CAS number for Semaglutide?
- The CAS number for Semaglutide is 910463-68-2. Its molecular formula is C₁₈₇H₂₉₁N₄₅O₅₉ (MW 4,113.6 g/mol).
- What doses of Semaglutide are available wholesale?
- Wholesale Peptide Supply stocks Semaglutide in 5mg, 10mg, 20mg. Wholesale pricing is provided by quote based on order volume across 100–1,000 vials.
- Is Semaglutide third-party tested?
- Yes. Every lot of Semaglutide is tested by an independent third-party laboratory using HPLC/MS, and a per-lot Certificate of Analysis documenting identity and purity is available as a paid add-on.
- Is Semaglutide for human use?
- No. Semaglutide is sold strictly as a chemical reagent for in-vitro laboratory research and is not for human or veterinary use. Wholesale Peptide Supply is not a pharmacy or compounding facility.
- How do I get wholesale pricing for Semaglutide?
- Request a quote through our contact form or open a wholesale account. An account manager replies with volume pricing and lead times, typically within 10 minutes during business hours.
- Can I order Semaglutide in bulk?
- Yes. Semaglutide is available for bulk and wholesale orders, quoted by dose and volume across 100, 250, 500, and 1,000-vial bands. Submit the doses and quantities you need for a bulk quote; all material is sourced in the USA and third-party HPLC/MS tested.
- How is wholesale semaglutide reconstituted for research?
- Semaglutide ships as a lyophilized powder and is reconstituted with bacteriostatic or sterile water for in-vitro laboratory use, with diluent volume selected for the target assay concentration. Lyophilized material is typically stored at -20°C; reconstituted solution is kept at 2–8°C. This describes reagent handling only, not human or veterinary use.
- What is the difference between semaglutide and tirzepatide?
- Semaglutide is a single-pathway GLP-1 receptor agonist; tirzepatide is a dual-pathway agonist active at two receptor targets. They are not interchangeable in research models. See the wholesale tirzepatide page or the tirzepatide-vs-semaglutide guide for a full comparison.
- What should a semaglutide COA show?
- A complete semaglutide Certificate of Analysis confirms identity by HPLC retention time and mass spec, reports a quantitative purity percentage, verifies per-vial dose, and ties to a lot number traceable to the production run — issued by the independent testing lab, not a first-party summary.
Research Use Only
All products are intended solely for laboratory research purposes and are not for human or animal consumption. Must be handled by qualified professionals.
Related Compounds
GLP-1 & Metabolic
Tirzepatide
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Retatrutide
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BPC-157
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GHK-Cu
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