Anti-Aging & LongevityCAS 1380846-27-2

5-Amino-1-MQ

5-Amino-1-MQ is a small molecule inhibitor of nicotinamide N-methyltransferase (NNMT), affecting NAD+ and SAM availability and methylation capacity.

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5-Amino-1-MQ 50mg

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Overview

5-Amino-1-MQ is a small molecule inhibitor of nicotinamide N-methyltransferase (NNMT), affecting NAD+ and SAM availability and methylation capacity.

History

Developed as a selective, cell-permeable NNMT inhibitor; early studies showed dose-dependent effects on fat mass and metabolic markers.

Key Areas of Research

  • NNMT inhibition, NAD+ pathway
  • Adipogenesis, lipid signaling
  • SAM dynamics, one-carbon metabolism

References

  1. Ruf S. et al. (2019). J Med Chem 62(4):2060–2072.
  2. Neelakantan H. et al. (2018). Biochem Pharmacol 147:179–190.

Research Use Only

All products are intended solely for laboratory research purposes and are not for human or animal consumption. Must be handled by qualified professionals.

Related Compounds