Research Use Only. MOTS-C is sold as a chemical reagent for in-vitro laboratory research, not for human or veterinary use. It is not a drug, supplement, or compounded preparation. It must be handled by qualified professionals. Wholesale Peptide Supply is not a pharmacy or compounding facility under 503A or 503B.
Wholesale MOTS-C — Bulk Research Supply
Available sizes
In-stock orders ship same day when paid by 1 pm PT, Mon–Fri. Overnight available.
Buy MOTS-C wholesale and in bulk from a US-based research peptide supplier. Every lot is sourced in the USA and third-party tested, with the lab and method on each lot's certificate. Bulk MOTS-C is quoted by dose and volume from a 3-kit (30-vial) order minimum, mix and match across doses and compounds; lower prices are earned at 10 kits and again at 100 kits in the order, mix and match.
MOTS-c is a mitochondria-derived peptide studied for its role in AMPK pathway activation, mitochondrial-nuclear signaling, and systemic metabolic regulation.
Wholesale Catalog
Available Doses
Published per-vial wholesale pricing for MOTS-C. Sold in kits of 10 vials with a 3-kit (30-vial) order minimum, mix and match across doses and compounds; lower prices apply at 10 kits and at 1,000+ vials in the order. Contact us for larger or custom-volume quotes — answered the same day. Urgent? Text or call (714) 625-9215 — you’ll reach a real person in the United States, not a chatbot or an overseas call center.
MOTS-C 10mg
WPSMS10 · CAS 1627580-64-6 · Anti-Aging & Longevity
- 1–9 kits
- $16.50/vial$14.85 paying by card
- 10–99 kits
- $13.20/vial$11.88 paying by card
- 100+ kits
- $12.16/vial$10.94 paying by card
10% off with card Every product, every volume band — taken off at checkout when you choose card.
Sold in kits of 10 vials · 3-kit order minimum, mix and match · price set by the total kits in your order (BAC water not counted)
MOTS-C 20mg
WPSMS20 · CAS 1627580-64-6 · Anti-Aging & Longevity
- 1–9 kits
- $28.75/vial$25.88 paying by card
- 10–99 kits
- $23/vial$20.70 paying by card
- 100+ kits
- $18.40/vial$16.56 paying by card
10% off with card Every product, every volume band — taken off at checkout when you choose card.
Sold in kits of 10 vials · 3-kit order minimum, mix and match · price set by the total kits in your order (BAC water not counted)
MOTS-C 40mg
WPSMS40 · CAS 1627580-64-6 · Anti-Aging & Longevity
- 1–9 kits
- $58.22/vial$52.40 paying by card
- 10–99 kits
- $46.58/vial$41.92 paying by card
- 100+ kits
- $37.26/vial$33.53 paying by card
10% off with card Every product, every volume band — taken off at checkout when you choose card.
Sold in kits of 10 vials · 3-kit order minimum, mix and match · price set by the total kits in your order (BAC water not counted)
Questions? Text a rep or call (714) 625-9215 — a real person in the US answers.
Overview
MOTS-c is a mitochondria-derived peptide studied for its role in AMPK pathway activation, mitochondrial-nuclear signaling, and systemic metabolic regulation.
History
First described in 2015 following discovery of short open reading frames in mitochondrial DNA.
Structure and mechanism
MOTS-c is unusual among research peptides in that it is not encoded by the nuclear genome. It is a 16-residue peptide translated from a short open reading frame within the mitochondrial 12S rRNA gene — one of a small family of mitochondria-derived peptides identified after researchers began systematically reading short ORFs in mitochondrial DNA.
That origin is what makes it a distinct research target. In laboratory models MOTS-c is studied as a signal that travels outward from the mitochondrion, with work centering on AMPK pathway activation, the folate–methionine cycle intermediates that appear upstream of it, and retrograde mitochondrial-to-nuclear communication. At 2,171.5 g/mol (C₁₄₉H₂₆₀N₄₆O₄₆S₂) it is small relative to the acylated metabolic analogs, and it is typically examined for pathway activation rather than receptor occupancy.
Reconstitution and handling (research use)
Wholesale MOTS-c ships lyophilized. For in-vitro use it reconstitutes readily in bacteriostatic or sterile water, with diluent volume chosen to hit the assay's target concentration. The two cysteine-containing positions reflected in the formula's S₂ mean oxidation is worth controlling for: minimizing headspace and avoiding prolonged room-temperature exposure after reconstitution helps preserve the intended species.
Lyophilized powder is generally stored at -20°C away from light; reconstituted solution is kept at 2–8°C and used within the study's working window. These notes cover general laboratory handling of a chemical reagent only — not human or veterinary use.
Wholesale sourcing notes
MOTS-c is stocked wholesale in 10 mg, 20 mg, and 40 mg presentations — the widest dose range in our mitochondrial category, which suits dose-response work without splitting an order across suppliers. Every lot is US-sourced and third-party verified for identity, purity, and quantitation, with a per-lot COA included in every order.
Pricing is in three bands set by the order's total kits — 1–9 kits, 10–99 kits and 100+ kits (1,000 vials), mix and match — from a 3-kit (30-vial) order minimum, mix and match across doses and compounds. Labs running mitochondrial panels commonly pair MOTS-c with SS-31, which approaches the organelle from a structural rather than a signaling angle.
Certificates of Analysis
9 certificates are on file for MOTS-C — open any one to read the full report.
| Lot / Lab | Dose | Tested | Purity | Certificate |
|---|---|---|---|---|
| 20260824-4Optiq Health LabsRP-HPLC / LAL | 20mg | 2026-10-08 | 99.4%Endotoxin Pass (≤0.05 EU/mg) | |
| 20260818-2Optiq Health LabsRP-HPLC / LAL | 40mg | 2026-10-08 | 99.8%Endotoxin Pass (≤0.05 EU/mg) | |
| DPS-2057663Horizon AnalyticalUPLC/MS | 10mg | 2026-10-03 | 99.69%Endotoxin <0.05 EU/mL | |
| DPS-4168216Horizon AnalyticalUPLC/MS | 40mg | 2026-10-03 | 99.57%Endotoxin <0.05 EU/mL | |
| DPS-7659536Horizon AnalyticalUPLC/MS | 10mg | 2026-09-14 | 99.66%Endotoxin <0.05 EU/mL | |
| 100089-0936Optiq Health LabsRP-HPLC / LC-MS | 10mg | 2026-08-20 | — | |
| 100089-0937Optiq Health LabsRP-HPLC / LC-MS | 40mg | 2026-08-20 | — | |
| 100032-0299Optiq Health LabsRP-HPLC / LC-MS | 10mg | 2026-07-29 | — | |
| 100032-0305Optiq Health LabsRP-HPLC / LC-MS | 40mg | 2026-07-29 | — |
Key Areas of Research
- AMPK activation
- Mitochondrial-nuclear signaling
- Glucose regulation, insulin sensitivity
References
- Lee C. et al. (2015). Cell Metab 21(3):443–454.
- Yen K. et al. (2020). Aging 12(13):12660.
MOTS-C — Frequently Asked Questions
- What is MOTS-C?
- MOTS-c is a mitochondria-derived peptide studied for its role in AMPK pathway activation, mitochondrial-nuclear signaling, and systemic metabolic regulation.
- What is the CAS number for MOTS-C?
- The CAS number for MOTS-C is 1627580-64-6. Its molecular formula is C₁₄₉H₂₆₀N₄₆O₄₆S₂ (MW 2,171.5 g/mol).
- What doses of MOTS-C are available wholesale?
- Wholesale Peptide Supply stocks MOTS-C in 10mg, 20mg, 40mg. Wholesale pricing is provided by quote based on order volume, from a 3-kit (30-vial) order minimum, mix and match across doses and compounds.
- Is MOTS-C third-party tested?
- Yes. Every lot of MOTS-C is tested by an independent third-party laboratory, and a per-lot Certificate of Analysis documenting identity and purity is included with every order at no charge, issued in the name of Wholesale Peptide Supply. The most recent published lot, 20260824-4 (20mg), was tested by Optiq Health Labs on 8 October 2026 by RP-HPLC / LAL: purity 99.4%, endotoxin Pass (≤0.05 EU/mg). Every lot on file is listed with its certificate on this page.
- Is MOTS-C for human use?
- No. MOTS-C is sold strictly as a chemical reagent for in-vitro laboratory research and is not for human or veterinary use. Wholesale Peptide Supply is not a pharmacy or compounding facility.
- How do I get wholesale pricing for MOTS-C?
- Request a quote through our contact form or open a wholesale account. An account manager replies with volume pricing and lead times the same day. For anything urgent, text or call (714) 625-9215 to reach a real person in the US.
- Can I order MOTS-C in bulk?
- Yes. MOTS-C is available for bulk and wholesale orders, quoted by dose and volume, from a 3-kit (30-vial) order minimum, mix and match across doses and compounds, with lower prices at 10 kits and at 100 kits (1,000 vials) in the order. Submit the doses and quantities you need for a bulk quote.
- What makes MOTS-c different from other research peptides?
- MOTS-c is a mitochondria-derived peptide — it is encoded within mitochondrial DNA rather than the nuclear genome, and was first described in 2015 after short open reading frames in mtDNA were characterized. In laboratory models it is studied for AMPK pathway activation and mitochondrial-to-nuclear signaling rather than for classical receptor binding.
- What doses of MOTS-c are available wholesale?
- MOTS-c is stocked in 10 mg, 20 mg, and 40 mg vials, all sharing CAS 1627580-64-6 and per-lot third-party verification. The range is intended for dose-response work; each presentation can be ordered from a single kit within a 3-kit order, and every kit counts toward the order's price bands.
Related Compounds
Anti-Aging & Longevity
SS-31
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Epithalon
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NAD+
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GHK-Cu
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L-Glutathione
L-Glutathione is a tripeptide serving as the primary intracellular antioxidant and redox regulator. Studied for ROS neutralization, redox homeostasis, and cellular integrity.
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5-Amino-1-MQ
5-Amino-1-MQ is a small molecule inhibitor of nicotinamide N-methyltransferase (NNMT), affecting NAD+ and SAM availability and methylation capacity.
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AHK-Cu
AHK-Cu (copper tripeptide-3) is the tripeptide Ala-His-Lys complexed with a copper(II) ion. It is studied alongside GHK-Cu in laboratory models of matrix signaling, follicular biology and vascular dynamics.
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Cartalax
Cartalax is a short synthetic peptide from the Khavinson bioregulator series, reported as the tripeptide Ala-Glu-Asp. It is studied in laboratory models of connective tissue and cartilage matrix signaling.
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