Research Use Only. MOTS-C is sold as a chemical reagent for in-vitro laboratory research. It is not a drug, supplement, or compounded preparation, and it is not for human or veterinary use. Wholesale Peptide Supply is not a pharmacy or compounding facility under 503A or 503B.
Wholesale MOTS-C — Bulk Research Supply
Buy MOTS-C wholesale and in bulk from a US-based research peptide supplier. Every lot is sourced in the USA and third-party third-party tested via HPLC/MS. Bulk MOTS-C is quoted by dose and volume from a 100-vial mix-and-match minimum; volume pricing is earned per compound at 100 kits.
MOTS-c is a mitochondria-derived peptide studied for its role in AMPK pathway activation, mitochondrial-nuclear signaling, and systemic metabolic regulation.
Wholesale Catalog
Available Doses
Published per-vial wholesale pricing for MOTS-C. Sold in kits of 10 vials with a 100-vial order minimum you can mix and match across compounds; volume pricing applies at 1,000+ vials. Contact us for larger or custom-volume quotes — typically answered within 10 minutes during business hours.
MOTS-C 10mg
WPSMS10 · CAS 1627580-64-6 · Anti-Aging & Longevity
$13.20/vial · under 100 kits · $10.56/vial · 100+ kits of this item
Sold in kits of 10 vials · 100-vial order minimum (mix & match across compounds) · 100+ kits of this item unlocks the lower price
MOTS-C 20mg
WPSMS20 · CAS 1627580-64-6 · Anti-Aging & Longevity
$23/vial · under 100 kits · $18.40/vial · 100+ kits of this item
Sold in kits of 10 vials · 100-vial order minimum (mix & match across compounds) · 100+ kits of this item unlocks the lower price
MOTS-C 40mg
WPSMS40 · CAS 1627580-64-6 · Anti-Aging & Longevity
$46.58/vial · under 100 kits · $37.26/vial · 100+ kits of this item
Sold in kits of 10 vials · 100-vial order minimum (mix & match across compounds) · 100+ kits of this item unlocks the lower price
Overview
MOTS-c is a mitochondria-derived peptide studied for its role in AMPK pathway activation, mitochondrial-nuclear signaling, and systemic metabolic regulation.
History
First described in 2015 following discovery of short open reading frames in mitochondrial DNA.
Structure and mechanism
MOTS-c is unusual among research peptides in that it is not encoded by the nuclear genome. It is a 16-residue peptide translated from a short open reading frame within the mitochondrial 12S rRNA gene — one of a small family of mitochondria-derived peptides identified after researchers began systematically reading short ORFs in mitochondrial DNA.
That origin is what makes it a distinct research target. In laboratory models MOTS-c is studied as a signal that travels outward from the mitochondrion, with work centering on AMPK pathway activation, the folate–methionine cycle intermediates that appear upstream of it, and retrograde mitochondrial-to-nuclear communication. At 2,171.5 g/mol (C₁₄₉H₂₆₀N₄₆O₄₆S₂) it is small relative to the acylated metabolic analogs, and it is typically examined for pathway activation rather than receptor occupancy.
Reconstitution and handling (research use)
Wholesale MOTS-c ships lyophilized. For in-vitro use it reconstitutes readily in bacteriostatic or sterile water, with diluent volume chosen to hit the assay's target concentration. The two cysteine-containing positions reflected in the formula's S₂ mean oxidation is worth controlling for: minimizing headspace and avoiding prolonged room-temperature exposure after reconstitution helps preserve the intended species.
Lyophilized powder is generally stored at -20°C away from light; reconstituted solution is kept at 2–8°C and used within the study's working window. These notes cover general laboratory handling of a chemical reagent only — not human or veterinary use.
Wholesale sourcing notes
MOTS-c is stocked wholesale in 10 mg, 20 mg, and 40 mg presentations — the widest dose range in our mitochondrial category, which suits dose-response work without splitting an order across suppliers. Every lot is US-sourced and third-party verified by HPLC/MS for identity, purity, and quantitation, with a per-lot COA available as a paid add-on.
Volume pricing runs across the 100, 250, 500, and 1,000-vial bands under a 100-vial mix-and-match minimum. Labs running mitochondrial panels commonly pair MOTS-c with SS-31, which approaches the organelle from a structural rather than a signaling angle.
Certificates of Analysis
Every lot of MOTS-C is tested by an independent third-party laboratory using HPLC/MS. 4 certificates are on file below — open any one to read the full report.
| Lot | Dose | Tested | Certificate |
|---|---|---|---|
| 100089-0936 | 10mg | 2026-08-20 | |
| 100089-0937 | 40mg | 2026-08-20 | |
| 100032-0299 | 10mg | 2026-07-29 | |
| 100032-0305 | 40mg | 2026-07-29 |
Key Areas of Research
- AMPK activation
- Mitochondrial-nuclear signaling
- Glucose regulation, insulin sensitivity
References
- Lee C. et al. (2015). Cell Metab 21(3):443–454.
- Yen K. et al. (2020). Aging 12(13):12660.
MOTS-C — Frequently Asked Questions
- What is MOTS-C?
- MOTS-c is a mitochondria-derived peptide studied for its role in AMPK pathway activation, mitochondrial-nuclear signaling, and systemic metabolic regulation.
- What is the CAS number for MOTS-C?
- The CAS number for MOTS-C is 1627580-64-6. Its molecular formula is C₁₄₉H₂₆₀N₄₆O₄₆S₂ (MW 2,171.5 g/mol).
- What doses of MOTS-C are available wholesale?
- Wholesale Peptide Supply stocks MOTS-C in 10mg, 20mg, 40mg. Wholesale pricing is provided by quote based on order volume across 100–1,000 vials.
- Is MOTS-C third-party tested?
- Yes. Every lot of MOTS-C is tested by an independent third-party laboratory using HPLC/MS, and a per-lot Certificate of Analysis documenting identity and purity is available as a paid add-on.
- Is MOTS-C for human use?
- No. MOTS-C is sold strictly as a chemical reagent for in-vitro laboratory research and is not for human or veterinary use. Wholesale Peptide Supply is not a pharmacy or compounding facility.
- How do I get wholesale pricing for MOTS-C?
- Request a quote through our contact form or open a wholesale account. An account manager replies with volume pricing and lead times, typically within 10 minutes during business hours.
- Can I order MOTS-C in bulk?
- Yes. MOTS-C is available for bulk and wholesale orders, quoted by dose and volume, with the lower price earned per compound at 100 kits (1,000 vials). Submit the doses and quantities you need for a bulk quote; all material is sourced in the USA and third-party HPLC/MS tested.
- What makes MOTS-c different from other research peptides?
- MOTS-c is a mitochondria-derived peptide — it is encoded within mitochondrial DNA rather than the nuclear genome, and was first described in 2015 after short open reading frames in mtDNA were characterized. In laboratory models it is studied for AMPK pathway activation and mitochondrial-to-nuclear signaling rather than for classical receptor binding.
- What doses of MOTS-c are available wholesale?
- MOTS-c is stocked in 10 mg, 20 mg, and 40 mg vials, all sharing CAS 1627580-64-6 and per-lot HPLC/MS verification. The range is intended for dose-response work; all three presentations count toward the 100-vial mix-and-match minimum.
Research Use Only
All products are intended solely for laboratory research purposes and are not for human or animal consumption. Must be handled by qualified professionals.
Related Compounds
Anti-Aging & Longevity
SS-31
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Cartalax
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