Research Use Only. LL-37 is sold as a chemical reagent for in-vitro laboratory research. It is not a drug, supplement, or compounded preparation, and it is not for human or veterinary use. It must be handled by qualified professionals. Wholesale Peptide Supply is not a pharmacy or compounding facility under 503A or 503B.
Wholesale LL-37 — Bulk Research Supply
Buy LL-37 wholesale and in bulk from a US-based research peptide supplier. Every lot is sourced in the USA and third-party tested via HPLC/MS. Bulk LL-37 is quoted by dose and volume from a 100-vial mix-and-match minimum; volume pricing is earned per compound at 100 kits.
LL-37 is the only known human cathelicidin peptide, a 37-residue amphipathic helix studied in laboratory models of antimicrobial activity, epithelial signaling and innate immune modulation.
Wholesale Catalog
Available Doses
Published per-vial wholesale pricing for LL-37. Sold in kits of 10 vials with a 100-vial order minimum you can mix and match across compounds; volume pricing applies at 1,000+ vials. Contact us for larger or custom-volume quotes — typically answered within 10 minutes during business hours.
LL-37 5mg
WPSLL5 · CAS 154947-66-7 · Immune & Inflammatory
$21.85/vial · under 100 kits · $17.48/vial · 100+ kits of this item
Sold in kits of 10 vials · 100-vial order minimum (mix & match across compounds) · 100+ kits of this item unlocks the lower price
Overview
LL-37 is the only known human cathelicidin peptide, a 37-residue amphipathic helix studied in laboratory models of antimicrobial activity, epithelial signaling and innate immune modulation.
History
Identified as the mature peptide released from the human CAMP gene product hCAP18, LL-37 has been extensively characterized in innate immunity research since the mid-1990s.
The only human cathelicidin
LL-37 is the sole cathelicidin-derived antimicrobial peptide found in humans, which is unusual — most mammals carry several — and is a large part of why it is so heavily studied.
It is a 37-residue amphipathic helix carrying a strong net positive charge. Both properties are mechanistically load-bearing: the cationic charge draws it to negatively charged bacterial membranes in preference to the more neutral outer face of mammalian cells, and the amphipathic helix lets it insert into and disrupt the lipid bilayer once there. Selectivity comes from that charge difference rather than from a receptor.
The same molecule also acts in innate immune signalling well beyond membrane disruption — binding bacterial lipopolysaccharide and acting in chemotaxis — which is why it appears in epithelial and wound-model research as readily as in antimicrobial assays.
A practical consequence of the cationic charge: LL-37 adsorbs strongly to negatively charged surfaces, so low-binding labware matters more here than for most peptides, and high-salt buffers can attenuate the membrane activity being measured. Supplied lyophilised, stored at -20°C protected from light, reconstituted solution refrigerated at 2-8°C.
Key Areas of Research
- Membrane interaction and antimicrobial mechanism
- Innate immune signaling and chemotaxis
- Epithelial and wound-model research
- Structure-activity work on cathelicidin fragments
References
- Dürr U.H.N. et al. (2006). LL-37, the only human member of the cathelicidin family of antimicrobial peptides. Biochim Biophys Acta, 1758(9):1408–1425.
- Vandamme D. et al. (2012). A comprehensive summary of LL-37, the factotum human cathelicidin peptide. Cell Immunol, 280(1):22–35.
LL-37 — Frequently Asked Questions
- What is LL-37?
- LL-37 is the only known human cathelicidin peptide, a 37-residue amphipathic helix studied in laboratory models of antimicrobial activity, epithelial signaling and innate immune modulation.
- What is the CAS number for LL-37?
- The CAS number for LL-37 is 154947-66-7. Its molecular formula is C₂₀₅H₃₄₀N₆₀O₅₃ (MW 4,493.26 g/mol).
- What doses of LL-37 are available wholesale?
- Wholesale Peptide Supply stocks LL-37 in 5mg. Wholesale pricing is provided by quote based on order volume across 100–1,000 vials.
- Is LL-37 third-party tested?
- Yes. Every lot of LL-37 is tested by an independent third-party laboratory using HPLC/MS, and a per-lot Certificate of Analysis documenting identity and purity is included with every order at no charge, issued in the name of Wholesale Peptide Supply.
- Is LL-37 for human use?
- No. LL-37 is sold strictly as a chemical reagent for in-vitro laboratory research and is not for human or veterinary use. Wholesale Peptide Supply is not a pharmacy or compounding facility.
- How do I get wholesale pricing for LL-37?
- Request a quote through our contact form or open a wholesale account. An account manager replies with volume pricing and lead times, typically within 10 minutes during business hours.
- Can I order LL-37 in bulk?
- Yes. LL-37 is available for bulk and wholesale orders, quoted by dose and volume, with the lower price earned per compound at 100 kits (1,000 vials). Submit the doses and quantities you need for a bulk quote.
Related Compounds
Immune & Inflammatory
KPV
KPV is a small tripeptide derived from the C-terminus of α-MSH studied for cytokine signaling, NF-κB modulation, and epithelial barrier dynamics.
View details →Immune & Inflammatory
VIP
Vasoactive Intestinal Peptide is a 28-residue basic neuropeptide of the secretin/glucagon superfamily, studied as a VPAC1/VPAC2 receptor agonist in laboratory models of vascular, immune and neuroendocrine signaling.
View details →GLP-1 & Metabolic
Semaglutide
Semaglutide is a synthetic peptide analog that functions as a long-acting pathway agonist, structurally modified for extended half-life and improved target binding affinity. It is studied in preclinical and laboratory models for its ability to activate target pathways and modulate downstream molecular signaling associated with endocrine regulation.
View details →GLP-1 & Metabolic
Tirzepatide
Tirzepatide is a synthetic peptide that functions as a dual pathway agonist, designed as a once-weekly investigational compound studied in preclinical laboratory models for receptor-mediated signaling and modulation of downstream cascades.
View details →GLP-1 & Metabolic
Retatrutide
Retatrutide is a synthetic investigational peptide developed as a multi-pathway agonist, representing the next generation of metabolic research compounds. It activates multiple target receptor subtypes for broad systemic effects studied in preclinical models.
View details →Growth Hormone
Ipamorelin
Ipamorelin is a synthetic pentapeptide and selective secretagogue-type agonist with minimal off-target pathway interference, used to study endocrine signaling and somatotroph axis modulation.
View details →Recovery & Structural
BPC-157
BPC-157 is a synthetic pentadecapeptide composed of 15 amino acids, originally derived from a naturally occurring protein fragment in gastric tissue. It has been studied extensively for its potential influence on molecular signaling, structural remodeling, and angiogenic processes.
View details →Anti-Aging & Longevity
GHK-Cu
GHK-Cu is a naturally occurring copper-binding tripeptide studied for its role in molecular signaling, matrix remodeling, and pathway dynamics.
View details →